Research notes

LDL is a rough draft.
ApoB is the number.

Half of first heart attacks happen with a normal LDL. We measure what actually predicts the event.

What we measure

ApoB, Lp(a) once in a lifetime at minimum, LDL particle number, triglyceride-to-HDL ratio, fasting insulin, hs-CRP, and a coronary calcium score when age and risk call for it.

Why ApoB

Every atherogenic particle carries one ApoB. Counting particles beats weighing cholesterol. Two people with identical LDL-C can have very different particle counts, and very different risk.

Lp(a)

Genetic, largely fixed, and missed by almost every standard panel. Knowing it changes how aggressively everything else is treated.

Tools

Diet and load first, always. Then statins where they fit, ezetimibe, bempedoic acid, and PCSK9 inhibition when statins are not tolerated or not enough. The goal is a particle number, not a prescription.

Educational. Not medical advice. Treatment decisions are made by a licensed clinician with the patient. Nothing here describes a product as approved by any regulator.

501(c)(3) · Tax-deductible

Fund the work.

Treatment for veterans, first responders and the uninsured, and the registry that documents it.

Other amount or monthly